Modelling Nanomaterial Toxicity

Welcome to the MODENA COST Initiative site

This MODENA COST action is supported by COST, an intergovernmental framework for European Cooperation in Science and Technology, which allows the coordination of nationally-funded research on a European level. The following agencies coordinate the COST initiative.

COST is the European framework
for the transnational coordination of
nationally funded research. 
COST is supported by the
EU Framework Programme Horizon 2020


The MODENA COST Initiative:

Nanotechnology produces engineered nanomaterials (ENM) having new or enhanced physico-chemical properties in comparison to their micron-sized counterparts. Some of these properties, like the high surface area to volume ratio, make them potentially dangerous to humans as shown by research in NANOTOXICOLOGY. 

To promote the development of a new generation of ENM that are SAFE-by-DESIGN, an understanding of the relationship between the ENM STRUCTURE and biological ACTIVITY is needed. In this context the Quantitative Nanostructure-Toxicity Relationships (QNTR) computational modelling technique is an effective alternative to experimental testing since it enables the prediction of (eco)-toxicological effects based on ENM structure only.

The construction of QNTR models requires the integration of expertise of nanomaterial scientists, (eco)-toxicologists, and modellers from academia, regulatory agencies and industry. Therefore, a network for trans-disciplinary cooperation is needed. Thus the MODENACOST Action has been established to promote and to co-ordinate these inter-disciplinary collaborations, with the ultimate aim of producing QNTR models for ENM.

The important benefits from MODENA include: 

(i) the development of a new generation of SAFE-by-DESIGN ENM; 

(ii) the effective reduction of animal testing and 

(iii) The creation of transparent, validated and rigorous QNTR tools for regulatory purposes in the field of nanotoxicology according to OECD principles.

MODENA Events 2016

Training School: Safer-Nano-Design Summer School

June 12th-18th, Archamps, France

Applications for funded student places at this Training School are now closed. 



  • Chair of the Action:
    Prof Lang TRAN (UK)
  • Vice Chair of the Action:
    Prof Miguel BANARES (ES)
  • DC Rapporteurs:
    Prof. Pavle ANDJUS (RS)
  • DC Rapporteurs:
    Prof Lukas ROHR (CH) 
  • DC Rapporteurs:
    Prof. Venceslav KAUCIC (SI) 
  • Science officer of the Action:
    Dr Caroline WHELAN 
  • Administrative officer of the Action:
    Milena STOYANOVA
  • Grant Holder of the Action: 
    Bryony ROSS (UK)
  • Grant Holder of the Action: 
    Susan YOUNG (UK)
  • Grant Holder of the Action: 
    Dominique BALHARRY (UK)